91.   Yaman D., Averhoff B. (2024) Identification of subcomplexes and protein-protein interactions in the DNA transporter of Thermus thermophilus HB27. Biochim. Biophys. Acta-Biomembranes, in press


90.    Timmis, K., .... Müller, V.,  ... Averhoff, B. and 72 more authors. (2024) A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society. Microb. Biotechnol. 17:e14456

89.   Cowan, D.A., Albers, S.V., Antranikian, G., Atomi, H., Averhoff, B., Basen, M., Driessen, A.J.M., Jebbar, M., Kelman, Z., Kerou, M., Littlechild, J., Müller, V., Schönheit, P., Siebers, B., Vorgias, K. (2024) Extremophiles in a changing world. Extremophiles 28:26

88.    Pfefferle, K., Averhoff, B. (2023) Wax ester and triacylglycerol production in Acinetobacter baumannii: role in osmostress protection, reactive oxygen species and antibiotic sensitivity. ACS Infect. Dis., in press

87.    Kirchner, L., Müller, V., Averhoff, B. (2023) A temperature-dependent pilin promotor for production of thermostable enzymes in Thermus thermophilus. Microb. Cell Factories, in press

86.    König, P., Wilhelm, A., Schaudinn, C., Poehlein, A., Daniel, R., Widera, M., Averhoff, B., Müller, V. (2023) The VBNC state: a fundamental survival strategy for Acinetobacter baumannii. mBio, in press

85   Alberti, L., König, P., Zeidler, S., Poehlein, A., Daniel, R., Averhoff, B., Müller, V. (2023) Identification and characterization of a novel pathway for aldopentose degradation in Acinetobacter baumannii. Environ. Microbiol., in press

84.    Iruegas, R., Pfefferle, K., Goettig, S., Averhoff, B., Ebersberger, I. (2023) Feature architecture aware phylogenetic profiling indicates a functional diversification of type IVa pili in the nosocomial pathogen Acinetobacter baumannii. PLoS Genet., in press

83.    König, P., Averhoff, B., Müller, V. (2023) K+ homeostasis is important for survival of Acinetobacter baumannii ATCC 19606 in the nosocomial environment. Int. Microbiol., in press

82.     Hubloher, J.J., van der Sande, L., Schaudinn, C., Müller, V., Averhoff, B. (2023) The Tol-Pal system of Acinetobacter baumannii is important for cell division, antibiotic resistance and virulence. Int. Microbiol., in press



81.    Breisch, J., Schumm, C., Poehlein, A., Daniel, R., Averhoff, B. (2022) The carnitine degradation pathway of Acinetobacter baumannii and its role in virulence. Environ. Microbiol., 24 : 4437-4448.

80.    Djahanschiri, B., Di Venanzio, G., Distel, J.S., Breisch, J., Dieckmann, M.A., Goesmann, A., Averhoff, B., Goettig, S., Wilharm, G., Feldman, M.F., Ebersberger, I. (2022) Evolutionary stable gene clusters shed light on the common grounds of pathogenecity in the Acinetobacter baumannii complex. PLOS Genet., 18 : e1010020.

79.    Breisch, J., Huber, LS, Kraiczy, P., Hubloher, J, Averhoff, B. (2022) The b-ketoadipate pathway of Acinetobacter baumannii is involved in complement resistance and affects resistance against aromatic antibiotics. Environ. Microbiol. Rep. 14 : 170-178.

78.    Breisch, J., Bendel, M., Averhoff, B. (2022) The choline dehydrogenase BetA of Acinetobacter baumannii: a flavo-protein responsible for osmotic stress protection. Environ. Microbiol., 24 : 1052-1061.

77.    Kirchner, L., Averhoff, B,. (2022) DNA binding by pilins and their interaction with the inner membrane platform of the DNA transporter in Thermus thermophilus. Biochim. Biophys. Acta - Biomembr. 1869 : 183818.



76.     Hubloher, J.J., Schabacker, K., Müller, V., Averhoff, B. (2021) CsrA coordinates compatible solute synthesis in Acinetobacter baumannii. Microbiol. Spectr. 9 : e0129621.

75.    Averhoff, B., Kirchner, L., Pfefferle, K., Yaman, D. (2021) Natural transformation in Gram-negative bacteria thriving in extreme environments: from genes and genomes to proteins, structures and regulation. Extremophiles 25 : 513-526.

74.    König, P., Averhoff, B., Müller, V., (2021) K+ and its role in virulence of Acinetobacter baumannii. Int. J. Med. Microbiol. 311 : 151516.

73.    Yaman, D., Averhoff, B. (2021) Functional dissection of structural regions of the Thermus thermophilus competence protein PilW: Implication in secretin complex stability, natural transformation and pilus functions. Biochim. Biophys. Acta – Biomembr. 1863 : 183666.


72.    Pfefferle, K., Lopalco, P., Breisch, J., Siemund, A., Corcelli, A., Averhoff, B. (2020) In vivo synthesis of monolysocardiolipin and cardiolipin by Acinetobacter baumannii phospholipase D and effect on cationic antimicrobial peptide resistance. Environ. Microbiol. 22 : 5300-5308.

71.    Hubloher, J.J., Zeidler, S., Lamosa, P., Santos H., Averhoff, B., Müller, V. (2020) Trehalose-6-phosphate mediated phenotypic change in Acinetobacter baumannii. Environ. Microbiol. 22 : 5156-5166.

70.    König, P., Averhoff, B., Müller, V. (2020) A first response to osmostress in Acinetobacter baumannii: transient accumulation of K+ and its replacement by compatible solutes. Environ. Microbiol. 12 : 419-423.

69.    Neuhaus, A., Selvaraj, M., Salzer, R., Langer, J.D., Kruse, K., Kirchner, L., Sanders, K., Daum, B., Averhoff, B., Gold, V.A.M. (2020). Cryo-electron microscopy reveals two distinct type-IV pili assembled by the same bacterium. Nat. Commun. 11, 2231.

68.     Breisch, J., Averhoff, B. (2020) Identification of osmo-dependent and osmo-independent betaine-choline-carnitine transporters in Acinetobacter baumannii: role in osmostress protection and metabolic adaptation. Environ. Microbiol. 22 : 2724-2735.



67.    Neißner, K., Keller, H., Duchardt-Ferner, E., Hacker, C., Kruse, K., Averhoff, B., Wöhnert, J. (2019) NMR resonance assignments for the GSPII-B domain of the traffic ATPase PilF from Thermus thermophilus in the apo and the c-di-GMP-bound state. Biomol. NMR Assign. 13 : 383-390.

66.    Keller, H., Kruse, K., Averhoff, B., Duchardt-Ferner, E., Wöhnert, J. (2019) NMR resonance assignments for the GSPII-C domain of the PilF ATPase from Thermus thermophilus in complex with c-di-GMP. Biomol NMR Assign. 13 : 361-366.

65.    Runci, F., Gentile, V.,Frangipani, E., Rampioni, G., Leoni, L., Lucidi, M., Visaggio, D., Harris, G., Chen, W., Stahl, J., Averhoff, B., Visca, P. (2019) The contribution of active iron-uptake to Acinetobacter baumannii pathogenicity. Infect. Immun. 25 : 87.

64.    Foong, W. E., Tam, H.-K., Crames, J., Averhoff, B., Pos, K. M. (2019) The chloramphenicol/Hantiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J. Antimicrob. Chemother. 74 : 1192-1201.

63.    Kruse, K., Salzer, R., Averhoff, B. (2019) The traffic ATPase PilF interacts with the inner membrane platform of the DNA translocator and type IV pili from Thermus thermophilus. FEBS Open Bio 9 : 4-17.



62.    Breisch, J., Waclawska, I., Averhoff, B. (2018). Identification and characterization of a carnitine transporter in Acinetobacter baumannii. MicrobiologyOpen : e752.

61.    Blesa, A., Averhoff, B., Berenguer, J. (2018) Horizontal gene transfer in Thermus spp. Curr Issues Mol Biol. 29 : 23-36.

60.    Zeidler, S., Hubloher, J., König, P., Ngu, N.D., Scholz, A., Averhoff, B., Müller, V. (2018) Salt induction and activation of MtlD, the key enzyme in the synthesis of the compatible solute mannitol in Acinetobacter baumannii. MicrobiologyOpen : e00614.

59.    Kruse, K., Salzer, R., Joos, F., Averhoff, B. (2018) Functional dissection of the three N-terminal general secretory pathway II domains and Walker motives of the traffic ATPase PilF from Thermus thermophilus. Extremophiles 22 : 461-471.


58.    D’Imprima, E., Salzer, R., Bhaskara, R.M., Sánchez, R., Rose, I., Kirchner, L., Hummer, G., Kühlbrandt, W., Vonck, J., Averhoff, B. (2017) Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus. eLife 6 : e30483.

57.    Lopalco, P., Stahl, J., Annese, C., Averhoff, B., Corcelli, A. (2017) Identification of unique cardiolipin and monolysocardiolipin species in Acinetobacter baumannii. Scientific Reports 7 : 2972.


56.    Salzer, R., Edoardo D’Imprima, E., Gold, V.A.M., Rose, I., Drechsler, M., Vonck, J., Averhoff, B. (2016) Topology and structure/function correlation of ring- and gate-forming domains in the dynamic secretin complex of Thermus thermophilus. J. Biol. Chem. 291 : 14448-14456.

55.    Koenigs, A., Stahl, J., Averhoff, B., Göttig, S., Wichelhaus, T.A., Wallich, R., Zipfel, P.F., Kraiczy, P. (2016) CipA of Acinetobacter baumannii is a novel plasminogen and complement binding protein. J. Infect Dis. 213 : 1388-1399.

54.    Scholz, A., Stahl, J., de Berardinis, V., Müller, V., Averhoff, B. (2016) Osmotic stress response in Acinetobacter baylyi: Identification of a glycine-betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine betaine synthesis through a choline-responsive BetI repressor. Environ. Microbiol. Reports 8 : 316-322.

53.    Salzer, R., Kern, T., Joos, F., Averhoff, B. (2016) The Thermus thermophilus comEA/comEC operon is associated with DNA binding and regulation of the DNA translocator and type IV pili. Environ. Microbiol. 18 : 65-74.


52.    Weidensdorfer, M., Chae, J.I., Makobe, C., Stahl, J., Averhoff, B., Müller, V., Schürmann, C., Brandes, R., Wilharm, G., Ballhorn, W., Christ, S., Linke, D., Fischer, D., Göttig, S., Kempf, V. (2016) Analysis of endothelial adherence of Bartonella henselae and Acinetobacter baumannii using a dynamic human ex vivo infection model. Infect. Immun. 84 : 711-722.

51.    Stahl, J., Bergmann, H., Göttig, S., Ebersberger, I., Averhoff, B. (2015) Acinetobacter baumannii virulence is mediated by the concerted action of three phospholipases D. PLoS ONE 10: e0138360.

50.    Gold, V.A.M., Salzer R., Averhoff, B., Kühlbrandt, W. (2015) Structure of a type IV pilus machinery in the open and closed state. eLife 21 : 4.

49.    Salzer, R., Joos, F., Averhoff, B. (2015) Different effects of MglA and MglB on pilus-mediated functions and natural competence in Thermus thermophilus. Extremophiles 19 : 261-267.

48.    Blesa, A., César, C., Averhoff, B., Berenguer, J. (2015) Noncanonical cell-to-cell DNA transfer in Thermus spp. is insensitive to argonaute-mediated interference. J. Bacteriol. 197 : 138-146.

47.    Averhoff, B. (2015) Acinetobacter baumannii - understanding and fighting a new emerging pathogen. Environ. Microbiol. Rep. 7 : 6-8.

46.    Sand, M., Rodrigues, M., González, J.M., de Crécy-Lagard, V., Santos, H., Müller, V., Averhoff, B. (2015) Mannitol-1-phosphate dehydrogenases/phosphatases: A family of novel bifunctional enzymes for bacterial adaptation to osmotic stress. Environ. Microbiol. 17 : 711-719.



45.    Salzer, R., Herzberg, M., Nies, D.H., Joos, F., Rathmann, B., Thielmann, Y., Averhoff, B. (2014) Zinc and ATP binding of the hexameric AAA-ATPase PilF from T. thermophilus: Role in complex stability, piliation, adhesion, twitching motility and natural transformation. J. Biol. Chem. 289 : 30343-30354.

44.    Salzer, R., Kern, T., Joos, F., Averhoff, B. (2014) Environmental factors affecting the expression of type IV pilus genes as well as piliation of Thermus thermophilus. FEMS Microbiol. Lett. 357 : 56-62.

43.    Salzer, R., Joos, F., Averhoff, B. (2014) Type IV pilus biogenesis, twitching motility, and DNA uptake in Thermus thermophilus: discrete roles of antagonistic ATPases PilF, Pil1, and Pil2. Appl. Environ. Microbiol. 80 : 644-652.

42.    Sand, M., Stahl, J., Waclawska, I., Ziegler, C., Averhoff, B. (2014) Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environ. Microbiol. 16 : 1490-1502.


41.    Salzer, R., Herzberg, M., Nies, D.H., Biukovic, G., Grüber, G., Müller, V., Averhoff, B. (2013) The DNA uptake ATPase PilF of Thermus thermophilus: a reexamination of the zinc content. Extremophiles 17 : 697-698.

40.    Sand, M., Mingote, A.I., Santos, H., Müller, V., Averhoff, B. (2013) Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase. Environ. Microbiol. 15: 2187-2197.



39.    Nordgard, L., Brusetti, L., Raddadi, N., Traavik, T., Averhoff, B., Nielsen K.M. (2012) An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tracts of rats. BMC Res. Notes 5 : 170.

38.    Burkhardt, J., Vonck, J., Langer, J.D., Salzer, R., Averhoff, B. (2012) An unusual N-terminal ααβαββα fold of PilQ from T. thermophilus mediates ring formation and is essential for piliation. J. Biol. Chem. 287 : 8484-8494.



37.    Sand, M., de Berardinis, V., Mingote, A., Santos, H., Göttig, S., Müller, V., Averhoff, B. (2011) Salt adaptation in Acinetobacter baylyi: identification and characterization of a secondary glycine betaine transporter. Arch. Microbiol. 193 : 723-730.

36.    Burkhardt, J., Vonck, J., Averhoff, B. (2011) Structure and function of PilQ, a secretin of the DNA transporter from the thermophilic bacterium Thermus thermophilus HB27. J. Biol. Chem. 286 : 9977-9984.

35.    Köcher, S., Averhoff, B., Müller, V. (2011) Development of a genetic system for the moderately halophilic bacterium Halobacillus halophilus: generation and characterization of mutants defect in the production of the compatible solute proline. Environ. Microbiol. 8 : 2122-2131.

34.    Rose, I., Biukovic, G., Aderhold, P., Müller, V., Grüber, G., Averhoff, B. (2011) Identification and characterization of a unique, zinc containing transport ATPase essential for natural transformation in Thermus thermophilus HB27. Extremophiles 15 : 191-202.



33.    Göttig, S., Pfeifer, Y., Wichelhaus, T.A., Zacharowski, K., Bingold, T., Averhoff, B., Brandt, C., Kempf, V.A. (2010) Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 10 : 828-829.

32.    Averhoff, B., Müller, V. (2010) Exploring research frontiers in microbiology: recent advances in halophilic and thermophilic extremophiles. Res. Microbiol. 161 : 506-514.



31.    Schwarzenlander, C., Haase, W., Averhoff, B. (2009) The role of single subunits of the DNA transport machinery of Thermus thermophilus HB27 in DNA binding and transport. Environ. Microbiol. 4 : 801-808.

30.    Averhoff, B. (2009) Shuffling genes around in hot environments: the unique DNA transporter of Thermus thermophilus. FEMS Microbiol Rev. 33 : 6611-6626.



29.    Averhoff, B. (2008) The natural transformation system of Acinetobacter baylyi: a unique transport machinery. In: Acinetobacter Molecular Biology, Gerischer U (ed.) pp 119-139, Caister Academic Press, Norfolk, UK.



28.    Schwarzenlander, C., Averhoff, B. (2006) Characterization of DNA transport in the thermophilic bacterium Thermus thermophilus HB27. FEBS J., 273 : 4210-4218.

27.    Averhoff, B. (2006) Genetic systems for Thermus. In: Extremophiles (Methods in Microbiology), Rainey F & Oren A (eds), Vol. 35, pp 279-308, Oxford: Oxford Academic Press.

26.    Gohl, O., Friedrich, A., Hoppert, M., Averhoff, B. (2006) The thin pili of Acinetobacter sp. strain BD413 mediate adhesion to biotic and abiotic surfaces. Appl. Environ. Microbiol. 72 : 1394-1401.

25.    Rumszauer, J., Schwarzenlander, C., Averhoff, B. (2006) Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27. FEBS J., 273 : 3261-3272.



24.    Averhoff, B. (2004) DNA transport and natural transformation in mesophilic and thermophilic bacteria. J. Bioenerg. Biomembr. 36 : 25-33.



23.    Averhoff, B., Friedrich, A. (2003) Type IV pili-related natural transformation systems: DNA transport in mesophilic and thermophilic bacteria. Arch. Microbiol. 18 : 385-393.

22.    Averhoff, B. (2003) Horizontaler Gentransfer in extrem thermophilen Mikroorganismen. Biospektrum 1 : 36-37.

21.    Stecker, C., Johann, A., Herzberg, C., Averhoff, B.,  Gottschalk, G. (2003) Complete nucleotide sequence and genetic organization of the 210-kb linear plasmid of Rhodococcus erythropolis BD2. J. Bacteriol. 185 : 5269-5274.

20.    Friedrich, A., Rumszauer, J., Henne, A., Averhoff, B. (2003) Pilin-like proteins in the extremely thermophilic Thermus thermophilus HB27: implication in competence for natural transformation and links to type IV pili biogenesis. Appl. Environ. Microbiol. 69 : 3695-3700.



19.    Friedrich, A., Prust, C., Hartsch, T., Henne, A., Averhoff, B. (2002) Molecular analyses of the natural transformation machinery and identification of pilus structures in the extremely thermophilic bacterium Thermus thermophilus strain HB27. Appl. Environ. Microbiol. 68 : 745-755.



18.    Friedrich, A., Hartsch, T., Averhoff, B. (2001) Natural transformation in mesophilic and thermophilic bacteria: identification and characterization of closely related ComA-like competence factors in Acinetobacter sp. BD413 and Thermus thermophilus HB27. Appl. Environ. Microbiol. 67 : 3140-3148.



17.    Herzberg, C., Friedrich, A., Averhoff, B. (2000) comB, a novel competence gene required for natural transformation of Acinetobacter sp. BD413: identification, characterization and analysis of growth phase-dependent regulation. Arch. Microbiol. 173 : 220-228.

16.    Porstendörfer, D., Gohl, O, Mayer, F., Averhoff, B. (2000) ComP, a pilin-like protein essential for natural competence in Acinetobacter sp. BD413: regulation, modification by glycosylation, and cellular localization. J. Bacteriol. 182 : 3673-3680.



15.    Saeki, H., Akira, M., Furuhashi, K., Averhoff, B.,  Gottschalk, G. (1999) Degradation of trichloroethene by a linear-plasmid-encoded alkene monooxygenase in Rhodococcus corallinus (Nocardia corallina) B-276. Microbiology 145 : 1721-1730.

14.    Averhoff, B. (1999) Die natürliche Transformation Gram-negativer Bodenbakterien. Biospektrum 2 : 115-117.

13.    Busch, S., Rosenplänter, C., Averhoff, B. (1999) Identification and characterization of comE and comF, two novel pilin-like competence factors involved in natural transformation of Acinetobacter sp. BD413. Appl. Environ. Microbiol. 65 : 4568-4574.



12.    Link, C., Eickernjäger, S., Porstendörfer, D., Averhoff, B. (1998) Identification and characterization of a novel competence gene, comC, required for DNA binding and uptake in Acinetobacter sp. strain BD413. J. Bacteriol. 180 : 1592-1595.

11.    Berendes, F., Sabarth, N., Averhoff, B., Gottschalk, G. (1998) Construction and use of an ipb DNA module to generate Pseudomonas strains with constitutive trichloroethene and isopropylbenzene oxidation activity. Appl. Environ. Microbiol. 64 : 2454-2462.



10.    Porstendörfer, D., Drotschmann, U., Averhoff, B. (1997) A novel competence gene, comP, is essential for natural transformation of Acinetobacter sp. BD413. Appl. Environ. Microbiol. 63 : 4150-4157.



9.      Pflugmacher, U., Averhoff, B., Gottschalk, G. (1996) Cloning, sequencing, and expression of isopropylbenzene degradation genes from Pseudomonas sp. strain JR1: identification of isopropylbenzene dioxygenase that mediates trichloroethene oxidation. Appl. Environ. Micrbiol. 62 : 3967-3977.

8.      Kesseler, M., Dabbs, E.R., Averhoff, B., Gottschalk, G. (1996) Studies on the isopropylbenzene 2,3-dioxygenase and the 3-isopropylcatechol 2,3-dioxygenase genes encoded by the linear plasmid of Rhodococcus erythropolis BD2. Microbiology 142 : 3241-3251.



7.      Dabrock, B., Kesseler, M., Averhoff, B., Gottschalk, G. (1994) Identification and characterization of a transmissible plasmid from Rhodococcus erythropolis BD2 that encodes isopropylbenzene and trichloroethylene catabolism. Appl. Environ. Microbiol. 60 : 853-860.



6.      Dimarco, A.A., Averhoff, B., Kim, E.E., Ornston, L.N. (1993) Evolutionary divergence of pobA, the structural gene encoding p-hydroxybenzoate hydroxylase in an Acinetobacter calcoaceticus strain well-suited for genetic analysis. Gene 125 : 25-33.

5.      Dimarco, A.A., Averhoff, B., Ornston, L.N. (1993) Identification of the transcriptional activator pobR, and characterization of its role in the expression of pobA, the structural gene for p-hydroxybenzoate hydroxylase in Acinetobacter calcoaceticus. J. Bacteriol. 175 : 4499-4506.



4.      Averhoff, B., Gregg-Jolly, L., Elsemore, D., Ornston, L.N. (1992) Genetic analysis of a supraoperonic clustering by use of natural transformation in Acinetobacter calcoaceticus. J. Bacteriol. 174 : 200-204.



3.      Hartnett, G., Averhoff, B., Ornston, L.N. (1990) Selection of Acinetobacter calcoaceticus mutants deficient in the p-hydroxybenzoate hydroxylase gene pobA, a member of a supraoperonic cluster. J. Bacteriol. 172 : 6160-6161.



2.      Averhoff, B., Gottschalk, G. (1988, 1992) Process for the microbiological preparation of 1,3-propane-diol from glycerol by Citrobacter. US Patent 5164309 A



1.      Averhoff, B., Antranikian, G., Gottschalk, G. (1985) Phosphorylation and nucleotidylation of proteins in Rhodocyclus gelatinosus. FEMS Microbiol. Lett. 33 : 299-304.